Project: Thyroid cancer in children
25,000 euros for research: Förderverein supports study on thyroid cancer in children
The Frankfurter Förderverein zur Bekämpfung von Tumorerkrankungen (FFBT) e.V. has handed over a cheque for 25,000 euros to Medical Clinic 1 at Frankfurt University Hospital. The funds will go towards a project focusing on molecular genetic analyses to improve diagnosis and treatment options for children and adolescents with thyroid cancer.
‘This donation is a valuable contribution to our clinic and the research work in the field of tumour diseases in young patients,’ emphasises Prof. Dr Stefan Zeuzem, Director of Stefan Zeuzem, Director of Medical Clinic 1 at the University Medical Centre University Medicine Frankfurt. ‘The funding is intended to support a study that systematically analyses demographic, clinical and clinical and, in particular, molecular genetic data on data on differentiated thyroid carcinomas and analyse analysed. Our research should help to improve improve diagnostics and develop targeted therapy options. develop targeted therapy options.’
The funded project is investigating how frequently certain genetic changes - in particular in the DICER1 gene - occur occur in childhood thyroid cancer and how they influence influence the course of the disease and treatment. In order to better understand these relationships, state-of-the-art molecular genetic molecular genetic analyses are used to better understand these relationships. In addition a standardised workflow will be developed in order to to diagnose affected children at an early stage and and provide them with a customised therapy.
Background: Thyroid cancer in children
Thyroid cancer is the most common malignant disease of the hormone-producing hormone-producing glands in adolescents. Between 2012 and 2016, these tumours accounted for around six per cent of all malignant cancers in young people under the age of 18. ‘Paediatric thyroid carcinomas often show a more aggressive more aggressive behaviour than in adults,’ says Dr Viktoria Florentine Köhler, senior physician specialising in Endocrinology, Diabetology, Nutritional Medicine at the Medical Clinic 1. Medical Clinic 1. ‘Thyroid cancer in young patients is often patients is only recognised at an advanced stage. recognised at an advanced stage. Studies show that certain genetic changes - in particular mutations in the DICER1 gene - are more common in affected children. occur more frequently in affected children. We want to collect comprehensive data on this.’
Collaboration for a larger database
The study is being conducted in close cooperation with the paediatric endocrinology paediatric endocrinology of the paediatric and adolescent medicine at the University Medicine Frankfurt, the University Centre for Centre for Tumour Diseases (UCT) Frankfurt, the Bürgerhospital Frankfurt and the University Medical Centre Mainz. In addition, the histopathological and and molecular genetic processing of the biosamples in collaboration with the Dr Senckenberg Institute for Pathology and Pathology and Human Genetics at the University Medical Centre Frankfurt.
‘The generous support from the Frankfurter Förderverein for the fight against tumour diseases makes it possible for us together with our partners to carry out urgently needed research work together with our partners. We want to better understand which mutations specifically occur in children with thyroid cancer and how we can develop targeted develop targeted therapeutic approaches that are tailored to the tailored to the individual genetic profiles of young patients,’ explains patients,’ explains Prof Dr Jörg Bojunga, Head of the Endocrinology, Diabetology, Nutritional Medicine at the University Medical Centre Frankfurt. ‘We are particularly pleased that one of the co-founders of the association, Prof Dr Kai Uwe Chow, has a long-standing connection connection to the University Medical Centre Frankfurt, which is now now contributing to the research and care of children and children and adolescents with thyroid cancer.’
The Förderverein
Prof Dr Kai Uwe Chow has habilitated at the University Medical Centre Frankfurt. Together with one of his patients, entrepreneur Ingo Söhngen, who was cured of a tumour disease cured of a tumour disease, he founded the Frankfurter Förderverein for the fight against tumour diseases. Ingo Söhngen is chairman of the board today. The FFBT has set itself the goal of to promote the treatment and care of patients with tumour patients with tumour diseases and to actively promote science actively support science and research in the field of cancer therapy. in the field of cancer therapy.
Picture material:
Ingo Söhngen and Prof Kai Uwe Chow (l.), founding members of the FFBT, hand over a symbolic cheque to cheque to the representatives of Medical Clinic 1, Prof. Dr Stefan Zeuzem (centre), Dr Viktoria Florentine Köhler and Prof Dr Jörg Bojunga.
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For more information:
Prof. Dr. Jörg Bojunga
Medizinische Klinik 1
Leiter Schwerpunkt Endokrinologie und Diabetologie, Ernährungsmedizin
Universitätsmedizin FrankfurtPhone: +49 63 01 – 87 68 1Mail:jörg.bojunga@unimedizin-ffm.deWeb:www.unimedizin-ffm.de
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